Evaluation of Enzyme inhibitors in drug discovery : a guide for medicinal chemists and pharmacologists

Resumen: The goal of this book is to provide chemists and pharmacologists with the key information they need to answer questions such as: What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism? How are inhibitors properly evalua...

Descripción completa

Autor Principal: Copeland, Robert Allen.
Formato: Libro
Idioma: Inglés
Publicación: Hoboken (New Jersey) : John Wiley & Sons, cop. 2005.
Series: Methods of biochemical analysis (John Wiley & Sons)
Materias:
Acceso en línea: Portada
covers
Bibliografía: Bibliografía
Índice analítico
Sumario : Resumen: The goal of this book is to provide chemists and pharmacologists with the key information they need to answer questions such as: What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism? How are inhibitors properly evaluated for potency, selectivity, and mode of action? What are the potential advantages and liabilities of specific inhibition modalities with respect to efficacy in vivo? And finally, what information should medicinal chemists and pharmacologist expect from their biochemistry/enzymology colleagues in order to most effectively pursue lead optimization?
ISBN: 0471686964
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

Portada
covers

USP Monteprincipe Sala

Signatura: 615 COP
Copia 10054220 No prestable